Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 644

年份

2023 49

2022 60

2021 43

2020 45

2019 45

2018 40

2017 47

2016 31

2015 28

2014 31

2013 25

2012 31

2011 11

2010 21

2009 13

2008 21

2007 23

2006 8

2005 10

2004 17

展开︾

关键词

优化 18

多目标优化 9

优化设计 8

遗传算法 6

企业 5

稳健设计 4

虚拟企业 4

不确定性 3

创新 3

一阶分析法 2

五品联动 2

人工智能 2

仿真优化 2

分布式优化 2

动态规划 2

可靠性灵敏度 2

工程 2

建筑企业 2

智能制造 2

展开︾

检索范围：

排序：展示方式：

Enterprise-wide optimization of integrated planning and scheduling for refinery-petrochemical complex

《化学科学与工程前沿（英文）》 2023年第17卷第10期页码 1516-1532 doi: 10.1007/s11705-022-2283-7

摘要： This paper focuses on the integrated problem of long-term planning and short-term scheduling in a large-scale refinery-petrochemical complex, and considers the overall manufacturing process from the upstream refinery to the downstream petrochemical site. Different time scales are incorporated from the planning and scheduling subproblems. At the end of each discrete time period, additional constraints are imposed to ensure material balance between different time scales. Discrete time representation is applied to the planning subproblem, while continuous time is applied to the scheduling of ethylene cracking and polymerization processes in the petrochemical site. An enterprise-wide mathematical model is formulated through mixed integer nonlinear programming. To solve the problem efficiently, a heuristic algorithm combined with a convolutional neural network (CNN), is proposed. Binary variables are used as the CNN input, leading to the integration of a data-driven approach and classical optimization by which a heuristic algorithm is established. The results do not only illustrate the detailed operations in a refinery and petrochemical complex under planning and scheduling, but also confirm the high efficiency of the proposed algorithm for solving large-scale problems.

关键词： planning scheduling refinery-petrochemical convolutional neural network heuristic algorithm

HTML PDF 收藏

Perspectives in multilevel decision-making in the process industry

Braulio BRUNAUD, Ignacio E. GROSSMANN

《工程管理前沿（英文）》 2017年第4卷第3期页码 256-270 doi: 10.15302/J-FEM-2017049

摘要： Decisions in supply chains are hierarchically organized. Strategic decisions involve the long-term planning of the structure of the supply chain network. Tactical decisions are mid-term plans to allocate the production and distribution of materials, while operational decisions are related to the daily planning of the execution of manufacturing operations. These planning processes are conducted independently with minimal exchange of information between them. Achieving a better coordination between these processes allows companies to capture benefits that are currently out of their reach and improve the communication among their functional areas. We propose a network representation for the multilevel decision structure and analyze the components that are involved in finding integrated solutions that maximize the sum of the benefits of all nodes of the decision network. Although such task is very challenging, significant research progress has been made in each component of this structure. An overview of strategic models, mid-term planning models, and scheduling models is presented to address the solution of each node in the decision network. Coordination mechanisms for converging the integrated solutions are also analyzed, including solving large-scale models, multiobjective optimization, bi-level programming, and decomposition. We conclude by summarizing the challenges that hinder the full integration of multilevel decision making in supply chain management.

关键词： supply chain optimization enterprise-wide optimization multilevel optimization planning scheduling

HTML PDF 收藏

数据驱动选矿过程优化研究进展

丁进良, 杨翠娥, 柴天佑

《工程（英文）》 2017年第3卷第2期页码 183-187 doi: 10.1016/J.ENG.2017.02.015

摘要：

在全球化的市场环境下，经济和环境的因素对复杂工业生产过程综合生产指标的优化提出了更高的要求，如提高生产效率、提高产品质量和产量，以及降低能源和资源的利用。本文简述了基于数据驱动的混合智能优化方法和技术在提高选矿过程全流程运行指标性能方面的最新进展。首先描述了选矿工业过程全流程综合指标优化问题，进而对涉及的数据驱动的优化方法进行总结。该全流程综合指标优化包含四个层次：综合生产指标优化(月综合生产指标)、日综合生产指标优化、运行指标优化和自动化系统设定值优化。最后，本文给出了选矿过程数据驱动优化的未来研究方向。

关键词：数据驱动的优化方法生产全流程的全局优化选矿过程勘查

HTML PDF 收藏

Research and establishment of enterprise quality metadata standard

SONG Han, LI Jie, ZHANG Genbao

《机械工程前沿（英文）》 2008年第3卷第1期页码 106-110 doi: 10.1007/s11465-008-0019-0

摘要： Enabling quality managers to utilize and manage quality data efficiently under modern quality management circumstances is a primary issue for improving enterprise quality management. A concept of quality metadata is proposed in this paper, which can help quality managers gain a deeper understanding of various features of quality data and establish a more stable foundation for further use and management of such data. The procedure of establishing quality metadata standards is emphasized in the paper, and the content structure and description scheme are given. Finally, a summary is made and future work is prospected.

关键词： enterprise quality foundation description quality management primary

HTML PDF 收藏

随机订单下制造企业的生产触发策略比较 Article

周龙飞, 张霖, 方亚隽

《工程（英文）》 2021年第7卷第6期页码 798-806 doi: 10.1016/j.eng.2021.03.012

摘要：

尽管新兴技术在制造系统中得到了广泛应用，但由于客户需求的多样性以及随机性，制造企业仍面临着如何保持高效灵活的生产的问题。由于加快订单交付速度与降低库存成本之间存在矛盾，所以制造企业如何制定合适的生产触发策略是其在动态环境中保持较高竞争力的关键所在。本文主要研究了制造企业在满足随机订单交付的同时降低库存成本的生产触发策略。提出的生产触发策略包括：时间触发策略、事件触发策略和混合触发策略。本文研究了不同生产触发策略的统一理论模型和仿真模型。在每种策略中都同时考虑并实施了零件生产触发策略和产品组装触发策略。在时间触发策略和混合触发策略中还同时考虑了触发周期对系统性能的影响。实验结果表明，如果触发周期设置合适，混合触发策略和时间触发策略能够获得比事件触发策略更快的订单交付时间和更低的库存成本。

关键词：协同制造生产触发优化仿真企业

HTML PDF 收藏

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

《农业科学与工程前沿（英文）》 2016年第3卷第2期页码 102-112 doi: 10.15302/J-FASE-2016100

摘要： Plants are frequently affected by pathogen infections. To effectively defend against such infections, two major modes of innate immunity have evolved in plants; pathogen-associated molecular pattern-triggered immunity and effector-triggered immunity. Although the molecular components as well as the corresponding pathways involved in these two processes have been identified, many aspects of the molecular mechanisms of the plant immune system remain elusive. Recently, the rapid development of omics techniques (e.g., genomics, proteomics and transcriptomics) has provided a great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein interactions (PPIs) between plants and pathogens have been carried out and characterized at the network level. In this review, we introduce experimental and computational identification methods of PPIs, popular PPI network analysis approaches, and existing bioinformatics resources/tools related to PPIs. Then, we focus on reviewing the progress in genome-wide PPI networks related to plant–pathogen interactions, including pathogen-centric PPI networks, plant-centric PPI networks and interspecies PPI networks between plants and pathogens. We anticipate genome-wide PPI network analysis will provide a clearer understanding of plant–pathogen interactions and will offer some new opportunities for crop protection and improvement.

关键词： plant–pathogen interactions systems biology omics plant immunity protein–protein interaction network

HTML PDF 收藏

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

null

《医学前沿（英文）》 2015年第9卷第2期页码 146-161 doi: 10.1007/s11684-014-0373-8

摘要：

Obesity prevalence has increased in recent years. Lifestyle change fuels obesity, but genetic factors cause more than 50% of average variations in obesity. The advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity research. As of this writing, more than 73 obesity susceptibility loci have been identified in ethnic groups through GWAS. The identified loci explain only 2% to 4% of obesity heritability, thereby indicating that a large proportion of loci remain undiscovered. Thus, the next step is to identify and confirm novel loci, which may exhibit smaller effects and lower allele frequencies than established loci. However, achieving these tasks has been difficult for researchers. GWAS help researchers discover the causal loci. Moreover, numerous biological studies have been performed on the polygenic effects on obesity, such as studies on fat mass- and obesity-associated gene (FTO), but the role of these polygenic effects in the mechanism of obesity remains unclear. Thus, obesity-causing variations should be identified, and insights into the biology of polygenic effects on obesity are needed.

关键词： obesity genetics genome-wide association studies body mass index fat mass- and obesity-associated gene

HTML PDF 收藏

Strategic Guidance Effect of Large-Scale Construction Enterprise Growth to Programme Contracting

Feng Guo,Yi-qi Chen,Yi-qing Cai

《工程管理前沿（英文）》 2016年第3卷第3期页码 246-251 doi: 10.15302/J-FEM-2016034

摘要： In the case of single project management standing the major place, the management on the organizational level and project level is separated from each other in large-scale construction enterprises, and it is not long before program management theories applied to construction industry. Under the new situation of construction project clustering, how to choose projects has been the strategic decision for construction enterprises. Therefore, with the theory of program management and strategic management, this paper analyzes the relationship between the strategic growth of large-scale construction enterprises and program contracting, and attempts to provide meaningful ideas for enterprises to choose program from the strategic level.

关键词： large-scale construction enterprise enterprise growth programme contracting strategic interaction

HTML PDF 收藏

虚拟企业和谐机制研究

王硕,唐小我

《中国工程科学》 2004年第6卷第4期页码 82-85

摘要：

文章运用和谐理论与方法，探讨虚拟企业运作与发展要素划分、现状和谐性分析，研究其和谐机制，据此可随时分析虚拟企业系统的和谐状态，以针对性改进其运行，最后给出案例研究。

关键词：虚拟企业和谐机制协调要素

HTML PDF 收藏

Genome-wide identification and expression analysis of the β-amylase genes strongly associated with fruit

Hongxia MIAO,Peiguang SUN,Yulu MIAO,Juhua LIU,Jianbin ZHANG,Caihong JIA,Jingyi WANG,Zhuo WANG,Zhiqiang JIN,Biyu XU

《农业科学与工程前沿（英文）》 2016年第3卷第4期页码 346-356 doi: 10.15302/J-FASE-2016127

摘要： β-amylase (BAM) is an important enzyme involved in conversion of starch to maltose in multiple biological processes in plants. However, there is currently insufficient information on the BAM gene family in the important fruit crop banana. This study identified 16 genes in the banana genome. Phylogenetic analysis showed that MaBAMs were classified into four subfamilies. Most in each subfamily shared similar gene structures. Conserved motif analysis showed that all identified MaBAM proteins had the typical glyco hydro 14 domains. Comprehensive transcriptomic analysis of two banana genotypes revealed the expression patterns of in different tissues, at various stages of fruit development and ripening, and in responses to abiotic stresses. Most s showed strong transcript accumulation changes during fruit development and late-stage ripening. Some showed significant changes under cold, salt, and osmotic stresses. This finding indicated that might be involved in regulating fruit development, ripening, and responses to abiotic stress. Analysis of five hormone-related and seven stress-relevant elements in the promoters of further revealed that BAMs participated in various biological processes. This systemic analysis provides new insights into the transcriptional characteristics of the genes in banana and may serve as a basis for further functional studies of such genes.

关键词： β-amylase banana genome-wide identification fruit development abiotic stress

HTML PDF 收藏

Genome-wide association studies: inherent limitations and future challenges

null

《医学前沿（英文）》 2012年第6卷第4期页码 444-450 doi: 10.1007/s11684-012-0225-3

摘要：

Genome-wide association studies (GWAS) have achieved great success in identifying genetic variants related to complex human diseases such as cancer and have provided valuable insights into their genetic architecture. Recently, GWAS is quite the fashion in China. However, there are issues related to its nature. Enormous work needs to be done in the post-GWAS era. Deep sequencing followed by functional studies will be needed to elucidate the underpinning biological mechanisms and further translate GWAS findings into medical practice. Along with pharmacogenomics, the success of GWAS in identifying genetic risk factors and genetic differences in drug response has been gradually enabling personalized medicine. In this article, we used hepatocellular carcinoma (HCC) as an example to demonstrate some of the inherent limitations and summarized future challenges of GWAS.

关键词： genome-wide association studies (GWAS) genetic variant cancer limitation challenge

HTML PDF 收藏

基于循环经济的企业发展战略创新研究

王孝斌,王学军

《中国工程科学》 2006年第8卷第6期页码 89-91

摘要：

循环经济走新型工业化道路、实现可持续发展的有效途径。讨论了企业发展循环经济应重新审视和调整发展战略，在观念、组织、管理、制度、技术、产品等方面要有所创新的问题。

关键词：资源循环经济创新企业

HTML PDF 收藏

Genome-wide association study of the backfat thickness trait in two pig populations

Dandan ZHU,Xiaolei LIU,Rothschild MAX,Zhiwu ZHANG,Shuhong ZHAO,Bin FAN

《农业科学与工程前沿（英文）》 2014年第1卷第2期页码 91-95 doi: 10.15302/J-FASE-2014005

摘要： Backfat thickness is a good predictor of carcass lean content, an economically important trait, and a main breeding target in pig improvement. In this study, the candidate genes and genomic regions associated with the tenth rib backfat thickness trait were identified in two independent pig populations, using a genome-wide association study of porcine 60K SNP genotype data applying the compressed mixed linear model (CMLM) statistical method. For each population, 30 most significant single-nucleotide polymorphisms (SNPs) were selected and SNP annotation implemented using Build 10.2. In the first population, 25 significant SNPs were distributed on seven chromosomes, and SNPs on SSC1 and SSC7 showed great significance for fat deposition. The most significant SNP (ALGA0006623) was located on SSC1, upstream of the gene. In the second population, 27 significant SNPs were recognized by annotation, and 12 SNPs on SSC12 were related to fat deposition. Two haplotype blocks, M1GA0016251-MARC0075799 and ALGA0065251-MARC0014203-M1GA0016298-ALGA0065308, were detected in significant regions where the and genes were identified as contributing to fat metabolism. The results indicated that genetic mechanism regulating backfat thickness is complex, and that genome-wide associations can be affected by populations with different genetic backgrounds.

关键词： backfat thickness SNP chip genome-wide association study compressed mixed linear model pig